Proof of Concept and Efficacy

Proof of Concept and Efficacy Studies

Backbone of Drug Discovery

Proof of concept and efficacy studies are fundamental to the drug discovery pipeline, ensuring that animal models are thoroughly evaluated for efficacy, and novel compounds are screened for potential toxicity.

Proof of Concept and Efficacy Models

Proper interpretation and thorough analysis of these studies by a pathologist well versed in experimental rodent pathology is imperative for the drug development pipeline to run smoothly. Our pathologists and consultants have extensive experience evaluating a myriad of proof of concept and efficacy models. These include oncology models such as xenograft and syngeneic mouse tumor models as well as autochthonous models of tumor development. Our pathologists and consultants are also available to assess models of inflammation (for example, the DSS-colitis model), hypertension, diabetes, heart failure, and non-alcoholic steatohepatitis (NASH).

Toxicity Screening is Essential

Proof of concept studies are often the first time that novel compounds are introduced into living animals. As such, these studies can offer the first opportunity to begin searching for any evidence of test agent mediated toxicity. Our pathologists and consultants are more than happy to help you plan your proof of concept studies as well as help you ensure the appropriate use of your animal models to maximize the efficacy and toxicity data that can be obtained.

Expertise Matters

It is imperative that the evaluation of animal models are performed by experienced pathologists to maximize the data collected, and ensure appropriate analysis. Drug development is expensive and resource intensive, and incomplete or improperly designed proof of concept and efficacy studies can lead to high costs in terms of funding, supplies, and lives.

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